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One Day on The Liver
 

Scientific Program

Thursday, September 6, 2007 8:30 - 9:30 Plenary Session Audi Max
Chair: H. Klinkmann (Rostock, Germany) , B. Walpoth (Geneve, Switzerland)
08:30 THE IMPORTANCE OF THE ENDOTHELIUM IN HEALTH, DISEASE AND REGENERATION
J. Kirkpatrick (Mainz, Germany)
09:00 DEVELOPMENT OF MECHANICAL CIRCULATORY SUPPORT SYSTEMS AND APPLICATION OF THE RELATED TECHNOLOGIES TO ARTIFICIAL ORGANS
Y. Taenaka (Osaka, Japan)
9:30 - 10:00 Coffee Break
10:00 - 12:30 Renal Session - Working Group - Uremic Toxins
 Room E.06
Chair: R. Vanholder (Gent, Belgium), Chairman of ESAO Working Group Uremic Toxins
10:00 THE HISTORY AND ROLE OF EUTox IN UREMIC TOXICITY 
R. Vanholder (Gent, Belgium)
10:25 UREMIC TOXICITY: GENERAL OVERVIEW 
G. Cohen (Vienna, Austria)
10:50 SCIENTIFIC APPROACHES APPLIED BY EUTox 
J. Jankowki (Berlin, Germany)
11:15 UREMIC TOXINS AND ENDOTHELIUM 
P. Brunet (Marseille, France)
11:40 UREMIC TOXINS AND LEUKOCYTES 
G. Glorieux (Gent, Belgium)
12:05 THERAPEUTIC APPROACHES TO COPE WITH UREMIC TOXICITY
U. Baurmeister (Berlin, Germany)
12:45 - 13:45 ESAO Corporate Symposium: Milestones on the way from artificial organs to regenerative medicine Audi Max
Chair: I. Ledebo (Lund, Sweden), B. Walpoth (Geneve, Switzerland)
14:00 - 15:30 Renal Session - Hemodialysis and Modelling
 Room E.06
Chair: S. Di Giulio (Rome, Italy), A. Buscaroli (Bologna, Italy)
14:00 HOW TO AUTOMATICALLY IMPROVE DIALYTIC OUTCOMES? A COMPARTMENTAL MODEL APPROACH 21
G. Casagrande, R. Fumero, M.L. Costantino (Milan, Italy)
14:15 NOCTURNAL HEMODIALYSIS WITH THE GENIUS® DIALYSIS SYSTEM 26
R. De Smet, A.M. Dhondt, S. Eloot, S. Claus, R. Vanholder (Gent, Belgium)
14:30 TREATMENT OUTCOME OF HEPATITIS C IN HEMODIALYSIS PATIENTS 51
A. Sikole, P. Dzekova, N. Selja, M. Gaseva , M. Zabzun, S. Muharemi, A. Asani, V. Amitov, G. Selim, S. Gelev, S. Mena, V. Grunevska, M. Polenakovic (Skopje, Macedonia)
14:45 Kt/V IS GONE, AND INTEGRATIVE MEDICINE HAS COME IN A FIELD OF DIALYSIS THERAPY 155
T. Agishi, M. Akamatsu, Y. Okuno (Tokyo, Japan)
15:00 EVALUATION OF HEMODIALYSIS (HD) ADEQUACY USING ONLINE KT/V AND SINGLE-POOL VARIABLE-VOLUME (SPVV) UREA KT/V  193
A.E. Grzegorzewska, W. Banachowicz (Poznań, Poland)
15:15 HEMODIALYSIS MEMBRANES AND OXIDATIVE STRESS IN HEMODIALYSIS PATIENTS 204
P. Dejanov, V. Gerasimovska, A. Oncevski, A. Sikole, B. Dejanova (Skopje, Macedonia)
15:30-17:00 Coffee Break & Poster Session
17:00 - 18:00 Renal Session - Continuous venovenous hemodiafltration Room E.06
Chair: M. Polenakovic (Skopje, Macedonia) , K. Metodiev (Varna, Bulgaria)
17:00 THE FIRST EXPERIENCE OF APPLICATION SLOW CONTINUOUS THERAPY METHODS  ON “MULTIFILTRATE“ DEVICE IN THE REPUBLIC OF BELARUS 2
I. Rovdo, V. Kirkovsky, A. Korolik (Minsk, Belarus)
17:15 EASY AND EFFECTIVE WAY TO PREVENT HYPOTHERMIA IN ACUTE RENAL FAILURE (ARF) PATIENTS ON CONTINUOUS VENOVENOUS HEMODIAFILTRATION (CVVHDF) 22
J.W. Chang, E.Y. Im, S.J. Lee, H.S. Park, S.K. Park, S.B. Kim (Seoul, South Korea)
17:30 EXTENDED DAILY HEMODIAFILTRATION (EDHDF) IN THE THERAPY OF ACUTE RENAL FAILURE 44
E. Mesic, M. Atic  (Tuzla, Bosnia and Herzegovina)
17:45 CONTINUOUS RENAL REPLACEMENT THERAPY (CRRT) AND PLASMA EXCHANGE (PE) IN  CRITICALLY ILL NEWBORNS AND INFANTS 48
R. Ponikvar, A. Kandus, J. Kovač, V. Premru, B. Knap, A. Marn, Š. Grosek, A. Gostiša-Kornhauser, J. Primožič, J. Buturović (Ljubljana, Slovenia)
Thursday, September 6, 2007 8:30 - 9:30 Plenary Session Audi Max
Chair: H. Klinkmann (Rostock, Germany) , B. Walpoth (Geneve, Switzerland)
08:30 THE IMPORTANCE OF THE ENDOTHELIUM IN HEALTH, DISEASE AND REGENERATION
J. Kirkpatrick (Mainz, Germany)
09:00 DEVELOPMENT OF MECHANICAL CIRCULATORY SUPPORT SYSTEMS AND APPLICATION OF THE RELATED TECHNOLOGIES TO ARTIFICIAL ORGANS
Y. Taenaka (Osaka, Japan)
9:30 - 10:00 Coffee Break
10:00 - 11:30 Heart Session - Fluid Dynamics
 Audi Max
Chair: P. Verdonck (Ghent, Belgium), K. Affeld (Berlin, Germany)
10:00 GAS EXCHANGE IN VIRTUAL RESPIRATORY SYSTEM – SIMULATION OF VENTILATION WITHOUT LUNGS MOVEMENT 73
T. Golczewski (Warsaw, Poland)
10:15 A MULTISCALE MODELING OF THROMBOSIS USING COUPLING OF DISSIPATIVE PARTICLE DYNAMICS WITH CONTINUUM FINITE ELEMENT METHOD  136
N. Filipovic, M. Kojic, A. Tsuda (Kragujevac, Serbia)
10:30 NUMERICAL MODELING AND VISUALIZATION OF BLOOD DAMAGE IN THREE STANDARD MECHANICAL VALVES 137
L. Goubergrits, U. Kertzscher, K. Affeld (Berlin, Germany)
10:45 HEPATIC ARTERY/PORTAL VEIN FLOW COMPETITION DURING HYPOTHERMIC MACHINE PERFUSION OF THE LIVER 139
W. Hillewaert, Q. Liu, K. Vekemans, P. Segers, P. Verdonck, J. Pirenne, J. Brasil, D. Monbaliu (Leuven, Belgium)
11:00 EXPERIMENTAL STUDY OF PATIENT SPECIFIC KINK IN ARTERIO-VENOUS GRAFT USING PARTICLE IMAGE VELOCIMETRY 192
K. Van Canneyt, R. Kaminsky, L. Antiga, J. Tordoir, P. Verdonck, S. Eloot (Gent, Belgium)
11:15 DEVELOPMENT OF A SHEAR STRESS MEASUREMENT TECHNIQUE FOR VENTRICULAR ASSIST DEVICES 200
A. Berthe, U. Kertzscher, L. Goubergrits, C. Christensen, K. Affeld (Berlin, Germany)
11:30 - 12:30 Tissue Engineering-Symposium
Chair: S. Nehrer (Krems, Austria)
11:30 CLINICAL EXPERIENCE WITH THE CARTILAGE REGENERATION SYSTEM (CaReS)
S. Nehrer (Krems, Austria)
11:50 CULTIVATION OF CELLS IN A 3D COLLAGEN MATRIX
K. Lämmle (Stuttgart, Germany)
12:10 THE SPECIAL MEANING OF RISK MANAGEMENT REGARDING TISSUE ENGINEERING PRODUCTION PROCEDURES
M. Pichler (Krems, Austria)
12:45 - 13:45 ESAO Corporate Symposium - Milestones on the way from artificial organs to regenerative medicine
Chair: I. Ledebo (Lund, Sweden), B. Walpoth (Geneve, Switzerland)
12:45 Major contributions from the industry to the development of dialysis therapy: The three most important innovations from Fresenius      
J Vienken, Fresenius Medical Care, Bad Homburg, Germany      
13:00 Major contributions from the industry to the development of dialysis therapy: The three most important innovations from Gambro      
I Ledebo, Gambro, Lund, Sweden        
13:15 Convective forces for improved dialytic therapy      
C Tetta, Fresenius Medical Care, Bad Homburg, Germany      
13:30 From synthetic to biological separation devices      
B Krause, Gambro, Hechingen, Germany      
Thursday, September 6, 2007 14:00 - 15:30 Heart Session - Assist Device - Experimental Audi Max
Chair: U. Steinseifer (Aachen, Germany), J.F. del Canizo (Madrid, Spain)
14:00 LINEAR BLOODPUMP - FIRST RESULTS IN MOCK CIRCULATION 111
M. Grossmann, W. Juettner, J. Landrath, I. Merkel, J.D. Schmitto, F.A. Schoendube (Goettingen, Germany)
14:15 ANTITHROMBOGENICITY OF UNDULATION PUMP VENTRICULAR ASSIST DEVICES IMPLANTED INTO GOATS FOR MORE THAN 3 MONTHS WITHOUT ANTICOAGULANT 113
K. Imachi, A. Baba, Y. Shiraishi, T. Yambe, H. Liu, K. Sekine, I. Saito, T. Isoyama, A. Kouno, T. Ono, P. Dobsak, Y. Abe (Sendai, Japan)
14:30 IMPROVEMENT OF RECOVERY-DIRECTED LEFT VENTRICULAR ASSIST DEVICE (RDLVAD) SO AS TO EFFECTIVELY SUPPORT THE ENTIRE PROCESS OF RECOVERY FROM HEART FAILURE  117
K. Watanabe, F. Miyawaki, K. Yoshimoto (Saitama, Japan)
14:45 PEDIATRIC HEART SUPPORT WITH A NEWLY DEVELOPED, CATHETER BASED PULSATILE 12F ROTARY BLOOD PUMP; AN ANIMAL STUDY 122
F. Rega, I. Vantichelen, H. Bollen, F. Kirchhof, G. Derjung, R. Damen, Schwandtner, R. Lutz, B. Meyns (Leuven, Belgium)
15:00 IN VIVO EVALUATION OF THE EFFECTS OF PULSATILE VAD OPERATING MODE ON LV HEMODYNAMICS 124
P. Ferrazzi, M.Glauber, N. Borenstein, L. Behr, S. Rinaldi (Bergamo, Italy)
15:15 HISTOLOGICAL CHANGES IN A SHEEP MODEL OF CHRONIC HEART FAILURE INDUCED BY MULTIPLE SEQUENTIAL CORONARY MICROEMBOLIZATION 126
J.D. Schmitto, P. Ortmann, E. Hintze, C. Gielok, S.N. Gupta, A. Popov, R. Wachter, M. Grossmann, F.A. Schoendube (Goettingen, Germany)
15:30 - 17:00 Coffee Break & Poster Session
17:00 - 18:00 Heart Session - Modelling and Simulation Audi Max
Chair: H. Schima (Vienna, Austria), M. Darowski (Warsaw, Poland)
17:00 NEW ALGORITHMS FOR IMPROVEMENT OF THE ANALYSIS OF DATA FROM HEART VALVE PROSTHESES QUALIFICATION TESTS, BASED ON 1&2-DIMENSIONAL SIGNALS 142
K. Rohr, P. Kostka, Z. Nawrat (Zabrze, Poland)
17:15 BLOOD GLUCOSE PREDICTION IN TYPE I DIABETICS THROUGH AUTOREGRESSIVE MODEL 158
V. Canonico, D. Fruttini, E. Sarti, P.G. Fabietti (Perugia,  Italy)
17:30 MODELING OF GLUCOSE-INSULIN REGULATION DURING PERITONEAL DIALYSIS 160
M. Galach, A. Weryński, B. Lindholm (Warsaw Poland)
17:45 THE EFFECT OF THE ARTERIAL LUMPED PARAMETER MODEL STRUCTURE ON SELECTED VENTRICULAR AND CIRCULATORY PARAMETERS IN A PHYSICAL, NUMERICAL OR HYBRID MODEL 168
M. Kozarski, G. Ferrari, K. Zielinski, K.Gorczynska, K.J. Palko, A. Tokarz, M. Darowski (Warsaw, Poland)
 
Thursday, September 6, 2007 8:30 - 9:30 Plenary Session Audi Max
Chair: H. Klinkmann (Rostock, Germany) , B. Walpoth (Geneve, Switzerland)
08:30 THE IMPORTANCE OF THE ENDOTHELIUM IN HEALTH, DISEASE AND REGENERATION
J. Kirkpatrick (Mainz, Germany)
09:00 DEVELOPMENT OF MECHANICAL CIRCULATORY SUPPORT SYSTEMS AND APPLICATION OF THE RELATED TECHNOLOGIES TO ARTIFICIAL ORGANS
Y. Taenaka (Osaka, Japan)
9:30 - 10:00 Coffee Break
10:00 - 11:30 One Day on the Liver I Room E.11
Chair: C. Legallais (Compiegne, France), J. Vienken (Bad Homburg, Germany)
What is new in Japan and the US?
10:00 REPORT FROM THE USA
S. Ash (Lafayette, USA)
10:15 REPORT FROM JAPAN
H. Hirasawa (Chiba, Japan)
Aspects concerning the (patho)physiology of the failing liver
10:30 TOXINS IN LIVER FAILURE - WHAT IS RELEVANT, WHAT DO WE HAVE TO REMOVE?
M. Joannidis (Innsbruck, Austria)
10:50 COAGULATION, ANTICOAGULATION AND THE FAILING LIVER
D. Falkenhagen (Krems, Austria)
11:10 ALCOHOLIC LIVER CIRRHOSIS: SUCCESSFUL TREATMENT WITH NOVEL AUTOLOGOUS LIVER CELL TRANSPLANTATION PROCEDURE
T. Lindl (München, Germany)
11:30 - 12:30 Therapeutic progress in acute renal failure with new membranes - Symposium sponsored by Gambro 
Chair: R. Oberbauer (Linz, Austria)
11:30 FUNCTION AND FEATURES OF A NEW MEMBRANE TYPE
M. Storr (Hechingen, Germany)
11:50 REMOVAL OF FREE LIGHT CHAINS IN MYELOMA-INDUCED RENAL FAILURE
C. Hutchison (Birmingham, United Kingdom)
12:10 ANTI-INFLAMMATORY EXTRACORPOREAL THERAPIES IN CRITICALLY ILL PATIENTS
M. Joannidis (Innsbruck, Austria)
12:45 - 13:45 ESAO Corporate Symposium - Milestones on the way from artificial organs to regenerative medicine
 Audi Max
Chair: I. Ledebo (Lund, Sweden), B. Walpoth (Geneva, Switzerland)
12:45 Major contributions from the industry to the development of dialysis therapy: The three most important innovations from Fresenius  
J Vienken, Fresenius Medical Care, Bad Homburg, Germany  
13:00 Major contributions from the industry to the development of dialysis therapy: The three most important innovations from Gambro  
I Ledebo, Gambro, Lund, Sweden    
13:15 Convective forces for improved dialytic therapy  
C Tetta, Fresenius Medical Care, Bad Homburg, Germany  
13:30 From synthetic to biological separation devices  
B Krause, Gambro, Hechingen, Germany  
Thursday, Septmber 6 2007 14:00 - 15:30 One Day on the Liver II Room E.11
Chair: I. Sauer (Berlin, Germany), D. Falkenhagen (Krems, Austria)
Clinical application of liver support systems - where do we stand today?
14:00 PROMETHEUS: IMPACT ON PRURITUS
K. Rifai (Hannover, Germany)
14:15 MARS VERSUS PROMETHEUS IN CLINICAL PRACTICE: WHAT DO WE KNOW?
A. Wilmer (Leuven, Belgium)
14:30 SELECTIVE PLASMA FILTRATION THERAPY (SEPET) FOR LIVER FAILURE - EARLY CLINICAL EXPERIENCE
J. Rozga (Los Angeles, USA)
14:45 PLASMAPERESIS IN CASES OF LIVER FAILURE - A SIMPLE BUT EFFECTIVE CONCEPT
K. Inoue (Yokohama, Japan)
15:00 BIOARTIFICIAL LIVER SUPPORT FOR ACUTE DECOMPENSATION OF CHRONIC LIVER DISEASE: CLINICAL RESULTS
M. Millis (Chicago, USA)
15:30 - 17:00 Coffee Break & Poster Session
17:00 - 18:00  One Day on the Liver III Room E.11
Chair: I. Sauer (Berlin, Germany), V. Weber (Krems, Austria)
Concepts and Technologies
17:00 CELLS FOR BIOARTIFICIAL LIVER SUPPORT
R. Hoekstra (Amsterdam, The Netherlands)
17:15 DEVELOPMENT AND EVALUATION OF A NEW WHOLE-BLOOD PERFUSED BIOREACTOR
N. Kobayashi (Okayama, Japan)
17:30 HEPA WASH
B. Kreymann (Munich, Germany)
17:45 CARBON BLOCK VS. GRANULAR COLUMNS FOR BINDING OF LIVER FAILURE TOXINS
S. Ash (Lafayette, USA)
Friday, September 7, 2007 8:30 - 9:30 Plenary Session Audi Max
Chair: G. Rakhorst (Groningen, The Netherlands), S. Stefoni (Bologna, Italy)    
08:30 TOWARDS BIODEGRADABLE VASCULAR GRAFTS
B. Walpoth (Geneva, Switzerland)
09:00 REGENERATIVE MEDICINE IN THE AGE OF BIOTECHNOLOGY
M. Lysaght (Providence, USA)
09.30 - 10.00 Coffee Break
10:00 - 11:30 Liver Session I Room E.06
Chair: U. Baurmeister (Berlin, Germany) , S. Ash (Lafayette, USA)
10:00 DEVELOPMENT OF A BIOARTIFICIAL LIVER DEVICE WITH CULTURE OF HUMAN LIVER-DERIVED CELLS
V. Fonsato, M.B. Herrera, M. Caronna, S. Buttiglieri, G. Camussi, C. Tetta (Turin, Italy) 59
10:15 BIOARTIFICIAL LIVER BASED ON HOLLOW FIBER MEMBRANE: PHYSICAL AND BIOLOGICAL CHARACTERIZATION AT MICRO SCALE LEVEL
A. Gautier, H.-D. Lemke, M. Dufresne, C. Legallais (Compiègne, France) 60
10:30 THREE DIMENSIONAL GROWTH OF HEPATIC CELLS IN ALGINATE BEADS. STUDIES OF BEADS OPTIMIZATION FOR FLUIDISED BED BIOREACTOR
A. Kinasiewicz, A. Gautier, D. Lewinska, M. Dufresne, A. Smietanka, J. Bukowski, C. Legallais, A. Weryński (Warsaw, Poland) 62
10:45 FRACTIONATED PLASMA SEPARATION AND ADSORPTION IN ACUTE-ON-CHRONIC LIVER FAILURE PATIENTS RESULTS IN LOSS OF PRO- AND ANTICOAGULANT FACTORS
P. Evenepoel, B. Meijers, P. Verhamme, A. Wilmer, F. Nevens, K. Claes, D. Kuypers, Y. Vanrenterghem (Leuven, Belgium) 65
11:00 PROMETHEUS IN THE TREATMENT OF EXPERIMENTAL ACUTE LIVER FAILURE DECREASES INTRACRANIAL PRESSURE SIGNIFICANTLY
M. Ryska, T. Pantoflicek, E. Laszikova, O. Ryska, J. Prazak, E. Koblihova (Prague, Czech Republic) 70
11:15 ELAD® CELLULAR AND SYSTEM PERFORMANCE IMPROVEMENTS
J. Brotherton, D. He, S. Asslani, M. Millis (San Diego, USA) 205
11:30 - 12:40 Symposium Sponsored by Fresenius Medical Care
Chair: J. Vienken  (Bad Homburg, Germany)
How to improve the efficiency of blood purification therapy?  
11:30 RENAL PROGENITOR/STEM CELL THERAPY FOR THE TREATMENT OF ACUTE AND CHRONIC RENAL FAILURE  
D. Humes (Michigan, USA)  
12:00 ON LINE HDF IN THE CLINICAL SETTING  
R. Greenwood (Stevenage, United Kingdom)  
12:20 ON-LINE HEMODIAFILTRATION: THE MOST EFFECTIVE DIALYSIS MODALITY. CLINICAL EXPERIENCE AND RESULTS FROM THE HUNGARIAN FRESENIUS MEDICAL CARE NETWORK 53  
L. Vaslaki (Sopron, Hungary)  
12:45 - 13:45 Presidential Lunch Symposium Audi Max
Round table discussion:
FUTURE OF ARTIFICIAL ORGAN RESEARCH AND DEVELOPMENT
  Moderation: Y. Nosé (Houston, USA), E. Wolner (Vienna, Austria)
Participants: 
M. Lysaght (Providence, USA)
J. Long (Salt Lake City, USA)
B. Walpoth (Geneva, Switzerland)
G. Rakhorst (Groeningen, The Netherlands)
Y. Taenaka (Osaka, Japan)